Additive vasospasm; risk of hypertension. Monitor Closely (1)promazine, methylphenidate. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Adults20 to 30 milligrams (mg) given in divided doses 2 or 3 times a day, taken 30 to 45 minutes before meals. Monitor Closely (1)methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Common options include Adderall XR, Vyvanse, and Concerta. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Methylphenidate may diminish antihypertensive effects. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unknown. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Methylphenidate may diminish antihypertensive effects. Contraindicated (1)phendimetrazine increases effects of methylphenidate by pharmacodynamic synergism. Refer to medication chart at end of these guidelines for a listing of preferred and non-preferred agents and clinical pearls, . Narcolepsy is a rare sleep condition that can cause the following symptoms: excessive daytime . Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Use Caution/Monitor. Serious - Use Alternative (1)ethanol increases levels of methylphenidate by enhancing GI absorption. Monitor Closely (2)fluphenazine, methylphenidate. Ritalin LA Metadate CD Concerta . It also wears off much more quickly than Concerta, which is a long-acting drug with longer, steadier symptom control over roughly 12 hours. Either increases effects of the other by pharmacodynamic synergism. Monitor BP. Use Caution/Monitor. Monitor Closely (1)hydrocodone, methylphenidate. Applies only to oral form of both agents. only.trifluoperazine increases toxicity of methylphenidate by pharmacodynamic antagonism. esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor BP. Use Caution/Monitor. Monitor BP. Adding plans allows you to compare formulary status to other drugs in the same class. Monitor Closely (1)fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Monitor BP. Contraindicated (1)tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. This drug is available at the lowest co-pay. Potential for additive CNS stimulation. loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)benzhydrocodone/acetaminophen, methylphenidate. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Either increases effects of the other by pharmacodynamic synergism. Additive vasospasm; risk of hypertension. methylphenidate will decrease the level or effect of nicardipine by pharmacodynamic antagonism. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. salmeterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Monitor BP. clozapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Monitor BP. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Risk of acute hypertensive episode. Monitor Closely (1)iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Avoid or Use Alternate Drug. Risk of acute hypertensive episode. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate . Mechanism: unknown. Monitor Closely (1)prochlorperazine, methylphenidate. Monitor BP. Use Caution/Monitor. Monitor Closely (1)rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Either increases effects of the other by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Modify Therapy/Monitor Closely. Monitor BP. Monitor BP. Either increases effects of the other by pharmacodynamic synergism. perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Potential for additive CNS stimulation. Mechanism: pharmacodynamic synergism. Mechanism: unknown. Contraindicated. Monitor Closely (1)amoxapine, methylphenidate. Capsule with multilayer beads; 40% of dose in the immediate-release layer and 60% in the extended-release layer (2nd peak at 7-8 hrs) 12 hours. Risk of acute hypertensive episode. Contraindicated. Other (see comment). Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. safinamide increases effects of methylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of acute hypertensive episode. Risk of acute hypertensive episode. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of trandolapril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . Contraindicated. Modify Therapy/Monitor Closely. Monitor Closely (1)dexlansoprazole decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. Serious - Use Alternative (1)yohimbe, methylphenidate. Minor/Significance Unknown. Other (see comment). Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)imipramine, methylphenidate. Use Caution/Monitor. Sympathomimetics can antagonize the activity of some antihypertensive agents. Children 6 years of age and olderAt first, 5 mg 2 times a day, taken before breakfast and lunch. albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. Monitor BP. Either increases effects of the other by serotonin levels. Use Caution/Monitor. methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Use Caution/Monitor. nortriptyline, methylphenidate. Use Caution/Monitor. Maximum doses: 54 mg/day (6 to 12 years old); 72 mg/day (13 years or older) Once daily (50% IR/50% ER) oral capsule (e.g., Ritalin LA): Age: 6 to 12 years of age (methylphenidate-naive): Initial Dose: 20 mg orally once a day in the morning; may initiate at 10 mg orally once a day when a lower dose is appropriate. prochlorperazine, methylphenidate. Selegiline. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Contraindicated (1)benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. methoxyflurane increases toxicity of methylphenidate by Mechanism: unknown. Use Caution/Monitor. Other (see comment). Ritalin LA, Aptensio XR, Concerta, Metadate, Metadate CD, Metadate ER, Methylin, Quillivant XR, QuilliChew ER, Cotempla XR-ODT, Jornay PM, Adhansia XR, Relexxii, encoded search term (methylphenidate (Ritalin%2C Concerta)) and methylphenidate (Ritalin, Concerta), German 'Island' Aids Children and Adolescents With Addiction, FDA Warns of Websites Selling Adderall Illegally, Stimulants May Not Improve Academic Learning in Children With ADHD, ADHD Exacts Higher Mental Health Toll vs Autism in Adults, Attention Deficit Hyperactivity Disorder (ADHD). Minor (1)yerba mate increases effects of methylphenidate by pharmacodynamic synergism. Other (see comment). CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Use Caution/Monitor. Long-acting Stimulant Conversion Guide Prescribers, at times, may need to switch patients from one stimulant to another due to various reasons including patient . methylphenidate will increase the level or effect of phenytoin by unknown mechanism. Use Caution/Monitor. Minor (1)American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Mechanism: pharmacodynamic synergism. perphenazine, methylphenidate. Additive pressor effect. Use Caution/Monitor. methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Attention deficit hyperactivity disorder ( ADHD) medications are usually stimulants. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. For example, Ritalin 10 mg q4h is converted to Concerta 36 mg. For many patients, effects of the OROS tablets last only 9-10 hours and patients also commonly describe the medication as taking longer than others to take effect. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor BP. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Mechanism: unknown. Other (see comment). Modify Therapy/Monitor Closely. Use Caution/Monitor. isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Risk of acute hypertensive episode. and formulary information changes. Other (see comment). Monitor Closely (1)loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Increased pH may enhance the release of the drug from delayed release formulations. Risk of acute hypertensive episode. Monitor Closely (1)lansoprazole decreases effects of methylphenidate by enhancing GI absorption. methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Minor (1)desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Risk of acute hypertensive episode. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Currently on methylphenidate 5 mg BID or . apomorphine, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Risk of acute hypertensive episode. Contraindicated (1)selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. hydrocodone, methylphenidate. Risk of acute hypertensive episode. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Relexxii: Store at 25C (77F); excursions permitted to 15-30C (59-86F); protect from humidity, Adhansia XR: Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F); protect from light, Extended-release chewable (QuilliChew ER): Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F), Extended-release orally disintegrating (Cotempla XR-ODT): Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F); store in reusable travel case, Immediate-release (Ritalin): Store at 25C (77F); excursions permitted to 15-30C (59-86F); protect from light. Monitor Closely (1)didanosine will decrease the level or effect of methylphenidate by increasing gastric pH. Contraindicated. Additive vasospasm; risk of hypertension. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor Closely (1)methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. 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